Expanding access to underutilized drugs to prevent and treat postpartum haemorrhage (AMPLI-PPHI)

The project, implemented by Jhpiego, aims to reduce deaths from postpartum haemorrhage. It will be working in Democratic Republic of Congo, Guinea, Kenya and India and sharing program learning with an additional 13 countries. © Jhpiego/Indrani Kashyap — © Jhpiego/Indrani Kashyap

Catalyze early adoption of heat stable carbetocin, tranexamic acid and misoprostol in high burden countries to reduce maternal mortality.

Challenges

14 million women hemorrhage in childbirth each year. Four in five of the women who die live in low- and middle-income countries.

Solutions

This large scale pilot will generate operational evidence that will help guide scale-up of key PPH drugs in LMICs. The AMPLI-PPHI (Accelerating Measurable Progress and Leveraging Investments for Postpartum Hemorrhage Impact) project will catalyze uptake of heat-stable carbetocin for prevention, misoprostol for self-administered prevention, and tranexamic acid for treatment of postpartum haemorrhage.

“One life lost to postpartum hemorrhage is one life too many. Through Unitaid’s commitment to expand access to lifesaving drugs and our partnership with Ministries of Health, FIGO and PATH, we can prevent the deaths of thousands of women who experience severe bleeding after birth. We are honored to lead this project and use our decades-long experience in managing complications at birth to propel catalytic change across Africa and Asia and significantly reduce maternal deaths.”

Elaine Roman, Project Lead, Jhpiego

Progress so far

With tens of thousands of medicine doses already delivered and more than 1500 healthcare workers trained in the safe administration or delivery of the three medicines, the program is on track to reach an estimated 100,000 pregnant women across DRC, Kenya, India and Guinea each year. In June 2024, AMPLI-PPHI was expanded to run in two additional countries.

The impact we are seeking

Collectively with the other projects in Unitaid’s postpartum haemorrhage portfolio, the AMPLI-PPHI project will serve to reduce PPH-related deaths, which disproportionately affect women in low- and middle-income countries (LMICs), especially those who lack access to quality care due to poverty, geography, or cultural barriers. Nearly all maternal deaths from bleeding after childbirth occur in LMICs, mostly in sub-Saharan Africa and South Asia (80% of all deaths).

At scale, these projects could reduce deaths from PPH by more than 10% within 5 years from the projects’ end. This supports the Sustainable Development Goal to reduce the global maternal mortality rate to fewer than 70 per 100,000 live births. This investment will also strengthen equity and bridge the gap in terms of access to quality and life-saving interventions for women who deliver in low-resource settings.